With no active cases of the virus in regional areas and no positive cases of COVID-19 reported in remote communities, the Kimberley borders are able to reopen to the rest of WA on Friday.
The restrictions were put in place on March 26 to protect WA's 274 remote Aboriginal communities from the coronavirus.
From Friday, June 5 the biosecurity restrictions will be removed, meaning the Kimberley, Shire of Ngaanyatjarraku and parts of the East Pilbara will reopen.
Access to remote communities will remain restricted under the state government's Emergency Management Act.
Aboriginal Affairs minister Ben Wyatt said when visiting these areas Western Australians must continue to practice social distancing and good hygiene.
"Aboriginal people, especially those living remotely, have a higher risk of getting sick from the coronavirus than other Western Australians," he said.
"All Western Australians are urged to be aware of the high vulnerability of remote communities and to follow the restrictions to help keep them safe."